Ospreys and Connacht are bringing forward their rearranged Pro14 match in Galway to Sunday 24 January, kick-off 15:00 BST.
The original match in late November was postponed after a Welsh regional player returned a positive Covid-19 test.
The game was initially rescheduled for 13 February but has been changed for a second time.
Welsh regions were facing two weeks off after the European Champions Cup and Challenge Cup were suspended.
Ospreys have won five out of the past six games and head coach Toby Booth is keen to avoid a long break.
“We want to keep playing. There’s a lot of positivity around the place,” he said.
“Winning does that, the culture you have does that, consistency does that. We want to maintain the vibe that you’ve created within the camp.”
Scarlets and Cardiff Blues will meet on 22 January while Dragons will next host Connacht on 5 February.